UG200 Series
A new era of sequencing
Twice the output.
Half the footprint.
Greater flexibility.
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UG200 Series:
Two configurations. Total flexibility.
With a simplified, more space-efficient design, the UG200 and UG200 Ultra significantly reduce footprint and weight while delivering results in as little as one day from library to data. Greater usability, faster project turnaround, and seamless scalability.
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UG200
A single-wafer system designed to be more affordable and accessible, enabling sequencing of 30,000 whole genomes per year at 30x coverage. Delivers immediate capability and long-term scalability with a seamless in-field upgrade path to the UG200 Ultra.
UG200 Ultra
A dual-wafer system offering extreme throughput capabilities for over 60,000 whole genomes per year at 30x coverage. Supported with powerful next generation compute capabilities, enabling faster data generation and a total wafer output of up to 60 wafers per week for certain applications.
Compare the UG200 and the UG200 Ultra
| UG200 | UG200 Ultra | |
|---|---|---|
| System Specifications | ||
| Wafer Capacity | 10 | 10 |
| Per-run wafer processing | Single wafer | Dual wafer |
| Output per Sequencing Run | ||
| PF reads per wafer (billion) | 16 to 20 | 16 to 20 |
| PF reads per sequencing run (billion) | 16 to 20 | 32 to 40 |
| Output per sequencing run (150bp)a | 2.7 Tb | 5.4 Tb |
| Output per sequencing run (200bp)a | 3.6 Tb | 7.2 Tb |
| Output per sequencing run (300bp)a | 5.4 Tb | 10.8 Tb |
| Sequencing Run Time | ||
| ~150bp Read lengthb | ~6.0 hrs | ~6.0 hrs |
| ~200bp Read lengthb | ~7.4 hrs | ~7.4 hrs |
| ~300bp Read lengthb | ~11.1 hrs | ~11.1 hrs |
| Weekly Output | ||
| Wafers per weekc (150bp Read length) | 30 | 60 |
| Wafers per weekc (300bp Read length) | 15 | 30 |
| Reads per weeka (150bp Read length) | 540 B | 1.08 T |
| Reads per weeka (300bp Read length) | 270 B | 540 B |
| Output per weeka,c | ~81 Tb | ~162 Tb |
| Application Throughput per week | ||
| 30x WGSa,d | 675 genomes | 1,350 genomes |
| 10x Flex v1a,e | 27 M cells | 54 M cells |
| Olink Explorer HTa,f | 10,320 samples | 20,640 samples |
a Based on 18B read per wafer throughput. Output depends on application, library quality, loading efficiency, and other experimental factors. A single flow cycle sequentially dispenses each distinct nucleotide (T, G, C, A) and correlates to 4 flows. Mostly natural sequencing-by-synthesis (SBS) flow sequencing does not result in only a single incorporated nucleotide in each sequencing colony in each flow and hence a simple average read length; instead, any number of nucleotides (e.g., 0, 1, 2, 3, 4, etc.) may be incorporated in each sequencing colony in each flow, resulting in a normal distribution of raw reads that is used to determine average read length.
b Runtime for sustained sequencing on the UG200™ Series sequencers; initial wafer loading adds ~2.3 h to sequencing runtime.
c Max productivity is achieved via a 5-day, single shift (8am - 5pm) work week with 7-day automated continuous sequencing enabled. Resultant wafer output is theoretical max productivity with 100% up time.
d 30x WGS = 400M reads/sample (~120Gb)
e 10x Flex v1 = 20k cells per sample * 10k reads per cell
f Olink Explore HT = 172 samples / 9B reads = 344 samples / wafer
UG200 Technology
Open wafer substrate
Enables transformative low cost and scalability
Ultima's revolutionary sequencing architecture replaces complex and expensive flow cells with a 200mm open wafer, a staple from the semiconductor industry. This innovation unlocks multiple improvements to reduce cost, increase performance, and provide a roadmap for scalability.
Continuous Sequencing
Built in automation for continuous data generation
Equipped with integrated automation and dual reagent drawers, the UG200 Series of sequencers can deliver over 65 hours of continuous operation. Its hot-swapping capability further extends run times while ensuring minimal operator intervention.
Rotational motion
Efficient, fast, and high-throughput
By using our open wafer and rotational motion to image, instead of micro-fluidics and cartesian scanning, the UG200 Series of sequencers imparts stability and efficiency for both contamination-free reagent delivery and rapid imaging.
Sample Capacity
Increased capacity for 10 samples
The UG200 can be loaded with 10 different pooled samples at once to enable continuous operation 7 days a week with minimal manual intervention, while supporting a variety of library types with customizable workflows and sequencing read lengths.
Unique mostly natural flow-based sequencing by synthesis
Ultima's unique single base flow chemistry was built for speed, efficiency, and accuracy where you need it most. Our chemistry inherently provides advantages for calling SNVs by asking how many nucleotides are added, but the base identity is never in question. Incorporating one type of nucleotide per flow enables an extremely low base substitution error rate.
Homopolymer accuracy above 99%
Average variant calling accuracy for homopolymer indels across GIAB samples HG001-HG007 was above 99% for all lengths up to 10 and remains high for all lengths up to 12 (F1 > 95% for hmer=12).
Powering the largest projects
The UG200 Series is engineered to drive the largest sequencing projects, whether whole genome sequencing, single-cell gene expression or protein detection. The UG200 Ultra can sequence 1,350 30X genomes, 5,400 single-cell samples (20K cells per sample) and over 20,000 proteomic assays per week.
Ecosystem of compatible applications
Library prep
Our Solaris 2.0 workflows are designed with simplicity, flexibility and ease of use in mind, offering seamless compatibility with leading third-party library prep providers. Ultima supports an open and collaborative ecosystem offering you the freedom to choose tools and workflows that best fit your application needs for impactful research.
Explore Solaris 2.0 workflowsAnalysis and bioinformatics
Leverage a suite of pre-configured pipelines optimized for Ultima data to efficiently execute analysis tasks in parallel with sequencing without affecting sequencing throughput. The UG200 series dedicated high-performance compute Server performs read and sample-level secondary analysis and outputs file formats compatible with third-party software tools.
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